
This hearty Meat Lovers Casserole solves the dinner dilemma when you're short on time but everyone wants something filling. It packs tons of protein, spicy pepperoni bits, and stretchy cheese into a family meal you'll have ready in under 60 minutes.
I whipped this up during my boy's birthday sleepover and all the kids wanted more. The grown-ups sneaked into the kitchen for tastes too, so now it shows up at every family get-together
Ingredients
- Rotini pasta: The twisty shape really grabs onto sauce. Pick a quality brand that won't turn mushy
- Ground beef: Gives that filling protein kick and rich taste. An 80% lean mix makes the juiciest result
- Kosher salt and pepper: Don't skip seasoning as you go. The bigger kosher salt grains spread flavor better
- Pepperoni slices: Adds that pizza joint flavor punch. Try thicker slices if you want something to bite into
- Mozzarella cheese: Creates those amazing stretchy strands when pulled. Grate it yourself for the smoothest melt
- Mild cheddar cheese: Brings a bit of tang and nice color. Skip pre-shredded bags for better texture
- Marinara sauce: Forms the tasty base. Even grocery store jars work fine, but pick one with herbs mixed in
- Italian seasoning: Packs in all those garden flavors. A new container will give you stronger aroma
Instructions
- Warm Up the Oven:
- Get your oven going at 375 degrees Fahrenheit before you start anything else. Give a nine by thirteen inch baking dish a good spray with cooking oil to make cleanup easier
- Cook the Beef:
- Put a big pan on medium-high heat and toss in your ground beef. Break it into chunks and add some kosher salt and pepper. Let it cook about eight to ten minutes until you don't see pink anymore. Stir it around often. When it's done, pour off the extra fat so your dish won't swim in grease
- Combine Everything:
- Into that same pan, dump your cooked rotini, all the pepperoni pieces, one cup of mozzarella, all the cheddar you've shredded, the whole jar of marinara, and a sprinkle of Italian seasoning. Mix it all up so sauce covers everything. Make sure you spread those pepperoni bits throughout for tasty surprises
- Layer in the Dish:
- Dump this mixture into your greased baking dish. Use a flat tool to push it into all the corners for even cooking. Scatter the last cup of mozzarella all over the top. This will turn into that beautiful golden layer everyone fights over
- Cook Until Bubbly:
- Stick the dish in your hot oven. Let it cook twenty-five to thirty minutes until cheese gets all melty and starts to brown. Cool it for a few minutes after taking it out. Cut into squares and maybe top with some fresh parsley if you're feeling fancy

I can't get enough of those crispy cheese bits along the edges where the cheddar gets all crunchy. My hubby and I once actually argued over who'd get the corner pieces, so these days I make two smaller batches just to keep things peaceful
Storage Tips
Wait till it's not hot anymore before you cover it up. It'll stay good in the fridge about three days. If you need longer, cut it into blocks and wrap them tight for freezing. This makes for quick lunches or dinners when you're too tired to cook
Ingredient Substitutions
Try ground turkey or Italian sausage instead of beef for different flavors. If you don't eat meat, go for fake crumbles or lots of chopped mushrooms. Want it spicier? Grab hot pepperoni or throw in some red pepper flakes
Serving Suggestions
Pair it with a simple green salad for balance. Some warm garlic bread or steamed veggies round things out nicely. Sometimes I pour extra marinara on top for more sauce. A sprinkle of fresh basil or parsley adds nice color and freshness
Cultural and Historical Context
After World War Two, busy American families fell in love with easy one-dish meals. This version takes pizza flavors we all crave but simplifies everything into a single pan. It's always gone fast at community dinners and gives you that pizza joy with homestyle comfort

You'll want this pizza-inspired cheesy goodness again and again. The dishes won't pile up and everyone leaves the table happy and full
Frequently Asked Questions
- → Which pasta shape is best?
Rotini works great, but try penne or fusilli for a fun twist.
- → What meats can I swap in?
You can mix it up with sausage, ground turkey, or even shredded chicken.
- → Should I cook the pasta first?
Yep, make sure to boil the pasta until firm but tender before using it in the dish.
- → How do I store leftovers?
Pop cooled leftovers into an airtight container and keep them in the fridge for up to three days.
- → Can I prep it early?
Totally! Put it all together ahead of time, refrigerate it, and bake when you're ready to eat.