Rich Meaty Casserole

Featured in Reliable Evening Meals.

Dive into a warm and satisfying dish full of ground beef, tasty pepperoni, and a mix of melted cheeses. Rotini pasta blends with zesty marinara and Italian herbs, baked until bubbling and golden on top. Easy to put together and packed with familiar ingredients, this layered casserole is perfect for family dinners. Finish it off with a sprinkle of parsley for a fresh touch. Serve hot and enjoy!

Aisha
Updated on Mon, 23 Jun 2025 20:42:32 GMT
A comforting bowl of meaty casserole with pasta, cheese, and hearty toppings. Pin it
A comforting bowl of meaty casserole with pasta, cheese, and hearty toppings. | cookingflavor.com

This hearty Meat Lovers Casserole solves the dinner dilemma when you're short on time but everyone wants something filling. It packs tons of protein, spicy pepperoni bits, and stretchy cheese into a family meal you'll have ready in under 60 minutes.

I whipped this up during my boy's birthday sleepover and all the kids wanted more. The grown-ups sneaked into the kitchen for tastes too, so now it shows up at every family get-together

Ingredients

  • Rotini pasta: The twisty shape really grabs onto sauce. Pick a quality brand that won't turn mushy
  • Ground beef: Gives that filling protein kick and rich taste. An 80% lean mix makes the juiciest result
  • Kosher salt and pepper: Don't skip seasoning as you go. The bigger kosher salt grains spread flavor better
  • Pepperoni slices: Adds that pizza joint flavor punch. Try thicker slices if you want something to bite into
  • Mozzarella cheese: Creates those amazing stretchy strands when pulled. Grate it yourself for the smoothest melt
  • Mild cheddar cheese: Brings a bit of tang and nice color. Skip pre-shredded bags for better texture
  • Marinara sauce: Forms the tasty base. Even grocery store jars work fine, but pick one with herbs mixed in
  • Italian seasoning: Packs in all those garden flavors. A new container will give you stronger aroma

Instructions

Warm Up the Oven:
Get your oven going at 375 degrees Fahrenheit before you start anything else. Give a nine by thirteen inch baking dish a good spray with cooking oil to make cleanup easier
Cook the Beef:
Put a big pan on medium-high heat and toss in your ground beef. Break it into chunks and add some kosher salt and pepper. Let it cook about eight to ten minutes until you don't see pink anymore. Stir it around often. When it's done, pour off the extra fat so your dish won't swim in grease
Combine Everything:
Into that same pan, dump your cooked rotini, all the pepperoni pieces, one cup of mozzarella, all the cheddar you've shredded, the whole jar of marinara, and a sprinkle of Italian seasoning. Mix it all up so sauce covers everything. Make sure you spread those pepperoni bits throughout for tasty surprises
Layer in the Dish:
Dump this mixture into your greased baking dish. Use a flat tool to push it into all the corners for even cooking. Scatter the last cup of mozzarella all over the top. This will turn into that beautiful golden layer everyone fights over
Cook Until Bubbly:
Stick the dish in your hot oven. Let it cook twenty-five to thirty minutes until cheese gets all melty and starts to brown. Cool it for a few minutes after taking it out. Cut into squares and maybe top with some fresh parsley if you're feeling fancy
A tasty pasta mix with meat and pepperoni, shown in a white dish. Pin it
A tasty pasta mix with meat and pepperoni, shown in a white dish. | cookingflavor.com

I can't get enough of those crispy cheese bits along the edges where the cheddar gets all crunchy. My hubby and I once actually argued over who'd get the corner pieces, so these days I make two smaller batches just to keep things peaceful

Storage Tips

Wait till it's not hot anymore before you cover it up. It'll stay good in the fridge about three days. If you need longer, cut it into blocks and wrap them tight for freezing. This makes for quick lunches or dinners when you're too tired to cook

Ingredient Substitutions

Try ground turkey or Italian sausage instead of beef for different flavors. If you don't eat meat, go for fake crumbles or lots of chopped mushrooms. Want it spicier? Grab hot pepperoni or throw in some red pepper flakes

Serving Suggestions

Pair it with a simple green salad for balance. Some warm garlic bread or steamed veggies round things out nicely. Sometimes I pour extra marinara on top for more sauce. A sprinkle of fresh basil or parsley adds nice color and freshness

Cultural and Historical Context

After World War Two, busy American families fell in love with easy one-dish meals. This version takes pizza flavors we all crave but simplifies everything into a single pan. It's always gone fast at community dinners and gives you that pizza joy with homestyle comfort

A pasta bowl filled with pepperoni and cheese, waiting to be enjoyed. Pin it
A pasta bowl filled with pepperoni and cheese, waiting to be enjoyed. | cookingflavor.com

You'll want this pizza-inspired cheesy goodness again and again. The dishes won't pile up and everyone leaves the table happy and full

Frequently Asked Questions

→ Which pasta shape is best?

Rotini works great, but try penne or fusilli for a fun twist.

→ What meats can I swap in?

You can mix it up with sausage, ground turkey, or even shredded chicken.

→ Should I cook the pasta first?

Yep, make sure to boil the pasta until firm but tender before using it in the dish.

→ How do I store leftovers?

Pop cooled leftovers into an airtight container and keep them in the fridge for up to three days.

→ Can I prep it early?

Totally! Put it all together ahead of time, refrigerate it, and bake when you're ready to eat.

Meaty Casserole Bake

Tasty pasta bake with beef, pepperoni, gooey cheese, and bold marinara sauce.

Prep Time
15 Minutes
Cook Time
25 Minutes
Total Time
40 Minutes
By: Aicha

Category: Dinner

Difficulty: Easy

Cuisine: American

Yield: 6 Servings (Makes one large dish)

Dietary: ~

Ingredients

→ Base

01 225 g rotini pasta, cooked just until firm

→ Meats

02 450 g ground beef
03 138 g slices of pepperoni

→ Dairy

04 226 g shredded mozzarella cheese
05 113 g shredded cheddar cheese (mild)

→ Sauce and Seasoning

06 680 g jar of marinara sauce
07 1 teaspoon blend of Italian herbs
08 0.5 teaspoon coarse kosher salt
09 0.25 teaspoon ground black pepper

Instructions

Step 01

Turn the oven to 190°C and get a 23x33 cm dish ready by spraying it lightly with nonstick spray.

Step 02

In a big pan over medium-high heat, toss in the ground beef. Sprinkle with some kosher salt and black pepper. Stir it around now and then, cooking for about 8-10 minutes until the beef is browned and fully cooked. Drain off the extra fat and set it aside.

Step 03

Take the skillet with the browned beef and add the cooked rotini, 113 g of the mozzarella, the pepperoni, the cheddar, marinara sauce, and Italian seasoning. Stir everything together so it's evenly combined.

Step 04

Pour the mixture into the dish you prepped earlier. Sprinkle the remaining 113 g of mozzarella evenly over the top.

Step 05

Pop the dish into the hot oven and bake for 25-30 minutes until the cheese is gooey and golden. Take it out and let it sit for a few minutes before serving. If you're feeling fancy, toss some fresh parsley on top.

Notes

  1. For better taste, go for good-quality pepperoni and freshly grate your cheeses.

Tools You'll Need

  • Big skillet
  • 23x33 cm baking dish
  • Oven

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Includes milk, gluten, and wheat.

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 532
  • Total Fat: 29 g
  • Total Carbohydrate: 38 g
  • Protein: 29 g